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Found 1 hit Enz. Inhib. hit(s) with Target = 'Sodium/glucose cotransporter 2' and Ligand = 'BDBM50344666'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50344666
PNG
(4-((5-(benzyloxymethyl)-4-(3,3,3-trifluoropropyl)-...)
Show SMILES FC(F)(F)CCn1c(COCc2ccccc2)nnc1CN1C(=O)COc2c(Cl)cc(Cl)cc12
Show InChI InChI=1S/C22H19Cl2F3N4O3/c23-15-8-16(24)21-17(9-15)31(20(32)13-34-21)10-18-28-29-19(30(18)7-6-22(25,26)27)12-33-11-14-4-2-1-3-5-14/h1-5,8-9H,6-7,10-13H2
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PC sid
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Similars
Article
PubMed
n/an/a 8n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair