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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Sodium/glucose cotransporter 2' and Ligand = 'BDBM50344676'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50344676
PNG
(6-chloro-8-nitro-4-((5-(5-(trifluoromethyl)pyridin...)
Show SMILES [O-][N+](=O)c1cc(Cl)cc2N(Cc3nnc(-c4ccc(cn4)C(F)(F)F)n3CCC(F)(F)F)C(=O)COc12
Show InChI InChI=1S/C20H13ClF6N6O4/c21-11-5-13-17(14(6-11)33(35)36)37-9-16(34)32(13)8-15-29-30-18(31(15)4-3-19(22,23)24)12-2-1-10(7-28-12)20(25,26)27/h1-2,5-7H,3-4,8-9H2
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Similars
Article
PubMed
n/an/a 7n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair