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Found 1 hit Enz. Inhib. hit(s) with Target = 'Sodium/glucose cotransporter 2' and Ligand = 'BDBM50344678'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50344678
PNG
(6-chloro-4-((5-(5-chloropyridin-2-yl)-4-propyl-4H-...)
Show SMILES CCCn1c(CN2C(=O)COc3c2cc(Cl)cc3[N+]([O-])=O)nnc1-c1ccc(Cl)cn1
Show InChI InChI=1S/C19H16Cl2N6O4/c1-2-5-25-16(23-24-19(25)13-4-3-11(20)8-22-13)9-26-14-6-12(21)7-15(27(29)30)18(14)31-10-17(26)28/h3-4,6-8H,2,5,9-10H2,1H3
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Similars
Article
PubMed
n/an/a 5n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair