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Found 1 hit Enz. Inhib. hit(s) with Target = 'Sodium/glucose cotransporter 2' and Ligand = 'BDBM50344680'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50344680
PNG
(4-((5-(5-chloropyridin-2-yl)-4-propyl-4H-1,2,4-tri...)
Show SMILES CCCn1c(CN2C(=O)COc3c(C)cc(C)cc23)nnc1-c1ccc(Cl)cn1
Show InChI InChI=1S/C21H22ClN5O2/c1-4-7-26-18(24-25-21(26)16-6-5-15(22)10-23-16)11-27-17-9-13(2)8-14(3)20(17)29-12-19(27)28/h5-6,8-10H,4,7,11-12H2,1-3H3
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Similars
Article
PubMed
n/an/a 3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair