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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Sodium/glucose cotransporter 2' and Ligand = 'BDBM50344683'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50344683
PNG
(6,8-dimethyl-4-((5-((1R,2R)-2-phenylcyclopropyl)-4...)
Show SMILES CCCn1c(CN2C(=O)COc3c(C)cc(C)cc23)nnc1[C@@H]1C[C@H]1c1ccccc1 |r|
Show InChI InChI=1S/C25H28N4O2/c1-4-10-28-22(26-27-25(28)20-13-19(20)18-8-6-5-7-9-18)14-29-21-12-16(2)11-17(3)24(21)31-15-23(29)30/h5-9,11-12,19-20H,4,10,13-15H2,1-3H3/t19-,20+/m0/s1
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Similars
Article
PubMed
n/an/a 8n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair