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Found 1 hit Enz. Inhib. hit(s) with Target = 'Sodium/glucose cotransporter 2' and Ligand = 'BDBM50344695'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50344695
PNG
(6,8-dichloro-4-((5-(2-methyl-2-phenylpropyl)-4-(3,...)
Show SMILES CC(C)(Cc1nnc(CN2C(=O)COc3c(Cl)cc(Cl)cc23)n1CCC(F)(F)F)c1ccccc1
Show InChI InChI=1S/C24H23Cl2F3N4O2/c1-23(2,15-6-4-3-5-7-15)12-19-30-31-20(32(19)9-8-24(27,28)29)13-33-18-11-16(25)10-17(26)22(18)35-14-21(33)34/h3-7,10-11H,8-9,12-14H2,1-2H3
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Article
PubMed
n/an/a 480n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...

Bioorg Med Chem Lett 21: 3774-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.053
BindingDB Entry DOI: 10.7270/Q2KK9C32
More data for this
Ligand-Target Pair