BindingDB PrimarySearch

Found 7 hits Enz. Inhib. hit(s) with Target = 'Sodium/glucose cotransporter 2' and Ligand = 'BDBM50386885'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM50386885 (CANAGLIFLOZIN \| CANAGLIFLOZIN HYDRATE \| US10752604...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					Assay Description Inhibition of human SGLT2 expressed in CHOK cells assessed as reduction of [14C]alpha-methyl-D-glucopyranoside uptake after 120 mins by liquid scinti...				Bioorg Med Chem 21: 5561-72 (2013) Article DOI: 10.1016/j.bmc.2013.05.048 BindingDB Entry DOI: 10.7270/Q2RX9DHV
Mitsubishi Tanabe Pharma Corporation Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM50386885 (CANAGLIFLOZIN \| CANAGLIFLOZIN HYDRATE \| US10752604...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Guangdong Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of SGLT2 (unknown origin)				Bioorg Med Chem 26: 3947-3952 (2018) Article DOI: 10.1016/j.bmc.2018.06.017 BindingDB Entry DOI: 10.7270/Q2P84FJN
Guangdong Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM50386885 (CANAGLIFLOZIN \| CANAGLIFLOZIN HYDRATE \| US10752604...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Haisco Pharmaceuticals Group Co. Ltd. Curated by ChEMBL					Assay Description Inhibition of human SGLT2 expressed in CHO cells assessed as decrease in uptake of [14C]AMG after 120 mins by TopCount method				J Med Chem 60: 4173-4184 (2017) Article DOI: 10.1021/acs.jmedchem.6b01818 BindingDB Entry DOI: 10.7270/Q2W37ZFS
Haisco Pharmaceuticals Group Co. Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM50386885 (CANAGLIFLOZIN \| CANAGLIFLOZIN HYDRATE \| US10752604...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
Jamia Hamdard Curated by ChEMBL					Assay Description Inhibition of human SGLT2				Eur J Med Chem 184: (2019) Article DOI: 10.1016/j.ejmech.2019.111773 BindingDB Entry DOI: 10.7270/Q2TT4V97
Jamia Hamdard Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM50386885 (CANAGLIFLOZIN \| CANAGLIFLOZIN HYDRATE \| US10752604...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	4.90	n/a	n/a	n/a	n/a	n/a	n/a
Je II Pharmaceutical Co., Ltd. US Patent					Assay Description To analyze a sodium-dependent glucose transport, cells for expressing hSGLT1 and hSGLT2 were seeded at 1�105 cells per well into a 96-well culture pl...				US Patent US10752604 (2020) BindingDB Entry DOI: 10.7270/Q2QF8WW2
Je II Pharmaceutical Co., Ltd. US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM50386885 (CANAGLIFLOZIN \| CANAGLIFLOZIN HYDRATE \| US10752604...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	6.70	n/a	n/a	n/a	n/a	n/a	n/a
Chugai Pharmaceutical Co. Ltd Curated by ChEMBL					Assay Description Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assay				Bioorg Med Chem 20: 4117-27 (2012) Article DOI: 10.1016/j.bmc.2012.04.053 BindingDB Entry DOI: 10.7270/Q26111CJ
Chugai Pharmaceutical Co. Ltd Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM50386885 (CANAGLIFLOZIN \| CANAGLIFLOZIN HYDRATE \| US10752604...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	2.20	n/a	n/a	n/a	n/a
Terns Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of SGLT2 (unknown origin)				J Med Chem 63: 5031-5073 (2020) Article DOI: 10.1021/acs.jmedchem.9b01701 BindingDB Entry DOI: 10.7270/Q2DJ5JXG
Terns Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)