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Found 1 hit Enz. Inhib. hit(s) with Target = 'Sodium/hydrogen exchanger 1' and Ligand = 'BDBM50115254'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium/hydrogen exchanger 1


(Rattus norvegicus)		BDBM50115254
PNG
(CHEMBL554227 | N-(2-phenyl-3,4-dihydro-2H-4-chrome...)
Show SMILES [#7]\[#6](-[#7])=[#7]\[#7]=[#6]-1-[#6]-[#6](-[#8]-c2ccccc-12)-c1ccccc1 |w:4.3|
Show InChI InChI=1S/C16H16N4O/c17-16(18)20-19-13-10-15(11-6-2-1-3-7-11)21-14-9-5-4-8-12(13)14/h1-9,15H,10H2,(H4,17,18,20)
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PubMed
n/an/a 3.30E+3n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibition

J Med Chem 45: 3009-21 (2002)


BindingDB Entry DOI: 10.7270/Q2V40VZN
More data for this
Ligand-Target Pair