BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Sodium/hydrogen exchanger 1' and Ligand = 'BDBM50115264'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium/hydrogen exchanger 1


(Rattus norvegicus)		BDBM50115264
PNG
(CHEMBL552934 | N-[3-methyl-6-(2-methylphenyl)-4,5,...)
Show SMILES Cc1c[nH]c2CC(CC(=NN=C(N)N)c12)c1ccccc1C |w:9.9,(4.35,-5.54,;5.44,-6.63,;5.44,-8.17,;6.77,-8.96,;8.08,-8.17,;9.43,-8.94,;10.76,-8.17,;10.76,-6.63,;9.43,-5.86,;9.43,-4.32,;10.76,-3.55,;10.76,-2.01,;12.09,-1.24,;9.41,-1.24,;8.1,-6.63,;12.09,-8.94,;12.09,-10.48,;13.42,-11.25,;14.75,-10.48,;14.75,-8.94,;13.42,-8.17,;13.42,-6.63,)|
Show InChI InChI=1S/C17H21N5/c1-10-5-3-4-6-13(10)12-7-14-16(11(2)9-20-14)15(8-12)21-22-17(18)19/h3-6,9,12,20H,7-8H2,1-2H3,(H4,18,19,22)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 34n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibition

J Med Chem 45: 3009-21 (2002)


BindingDB Entry DOI: 10.7270/Q2V40VZN
More data for this
Ligand-Target Pair