Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM50117271 (1-(2,6-dimethylphenoxy)-2-propanolamine | 1-(2,6-d...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of Nav1.5 (unknown origin)-mediated late channel current | Citation and Details Article DOI: 10.1016/j.bmcl.2021.128133 BindingDB Entry DOI: 10.7270/Q2CJ8J7B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM50117271 (1-(2,6-dimethylphenoxy)-2-propanolamine | 1-(2,6-d...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | 7.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd Curated by ChEMBL | Assay Description Inhibition of human NaV1.5 by IonWorks quattro automated electrophysiology assay | Bioorg Med Chem Lett 25: 5419-23 (2015) Article DOI: 10.1016/j.bmcl.2015.09.005 BindingDB Entry DOI: 10.7270/Q2930W06 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM50117271 (1-(2,6-dimethylphenoxy)-2-propanolamine | 1-(2,6-d...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Inhibition of human recombinant Nav1.5 channel expressed in HEK293 cells by whole cell voltage clamp technique | Bioorg Med Chem 16: 6379-86 (2008) Article DOI: 10.1016/j.bmc.2008.05.003 BindingDB Entry DOI: 10.7270/Q2VH5NNT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM50117271 (1-(2,6-dimethylphenoxy)-2-propanolamine | 1-(2,6-d...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | DrugBank | n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombin | Citation and Details | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM50117271 (1-(2,6-dimethylphenoxy)-2-propanolamine | 1-(2,6-d...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | 5.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Bari"Aldo Moro" Curated by ChEMBL | Assay Description Blockade of human full-length NaV1.5 expressed in HEK293 cells co-transfected with pCD8-IRES-hbeta1 assessed as 10 Hz of use-dependent-induced channe... | J Med Chem 55: 1418-22 (2012) Article DOI: 10.1021/jm201197z BindingDB Entry DOI: 10.7270/Q27S7PRH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM50117271 (1-(2,6-dimethylphenoxy)-2-propanolamine | 1-(2,6-d...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | 4.20E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Bari"Aldo Moro" Curated by ChEMBL | Assay Description Blockade of human full-length NaV1.5 expressed in HEK293 cells co-transfected with pCD8-IRES-hbeta1 assessed as 0.1 Hz of half-maximal tonic-induced ... | J Med Chem 55: 1418-22 (2012) Article DOI: 10.1021/jm201197z BindingDB Entry DOI: 10.7270/Q27S7PRH | |||||||||||
More data for this Ligand-Target Pair |