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Target
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Found
8
hits Enz. Inhib. hit(s) with Target = 'Sodium channel protein type 5 subunit alpha' and Ligand = 'BDBM50568138'
Target/Host
(Institution)
Ligand
Target/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
k
off
s
-1
k
on
M
-1
s
-1
pH
Temp
°C
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human))
BDBM50568138
(CHEMBL4854735)
Show SMILES
Fc1cccc(NS(=O)(=O)c2cc(F)c(O[C@H]3CCN(CC(F)(F)F)C[C@@H]3c3ccc(F)c(F)c3)c(F)c2)n1 |r|
Show InChI
PDB
KEGG
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GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
370
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Displacement of [3H]BNZA from Nav1.5 (unknown origin)
Citation and Details
Article DOI:
10.1016/j.bmcl.2021.128133
BindingDB Entry DOI:
10.7270/Q2CJ8J7B
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human))
BDBM50568138
(CHEMBL4854735)
Show SMILES
Fc1cccc(NS(=O)(=O)c2cc(F)c(O[C@H]3CCN(CC(F)(F)F)C[C@@H]3c3ccc(F)c(F)c3)c(F)c2)n1 |r|
Show InChI
PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
16
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of human Nav1.5 expressed in HEK293 cells assessed as inhibition of late channel current at holding potential of -95 mV
Citation and Details
Article DOI:
10.1016/j.bmcl.2021.128133
BindingDB Entry DOI:
10.7270/Q2CJ8J7B
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human))
BDBM50568138
(CHEMBL4854735)
Show SMILES
Fc1cccc(NS(=O)(=O)c2cc(F)c(O[C@H]3CCN(CC(F)(F)F)C[C@@H]3c3ccc(F)c(F)c3)c(F)c2)n1 |r|
Show InChI
PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
18
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of human Nav1.5 expressed in HEK293 cells assessed as inhibition of peak channel current at holding potential of -95 mV
Citation and Details
Article DOI:
10.1016/j.bmcl.2021.128133
BindingDB Entry DOI:
10.7270/Q2CJ8J7B
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human))
BDBM50568138
(CHEMBL4854735)
Show SMILES
Fc1cccc(NS(=O)(=O)c2cc(F)c(O[C@H]3CCN(CC(F)(F)F)C[C@@H]3c3ccc(F)c(F)c3)c(F)c2)n1 |r|
Show InChI
PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
39
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of human Nav1.5 by automated voltage clamp electrophysiology
Citation and Details
Article DOI:
10.1016/j.bmcl.2021.128133
BindingDB Entry DOI:
10.7270/Q2CJ8J7B
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human))
BDBM50568138
(CHEMBL4854735)
Show SMILES
Fc1cccc(NS(=O)(=O)c2cc(F)c(O[C@H]3CCN(CC(F)(F)F)C[C@@H]3c3ccc(F)c(F)c3)c(F)c2)n1 |r|
Show InChI
PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
44
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of human Nav1.5 expressed in HEK293 cells by sodium influx assay
Citation and Details
Article DOI:
10.1016/j.bmcl.2021.128133
BindingDB Entry DOI:
10.7270/Q2CJ8J7B
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human))
BDBM50568138
(CHEMBL4854735)
Show SMILES
Fc1cccc(NS(=O)(=O)c2cc(F)c(O[C@H]3CCN(CC(F)(F)F)C[C@@H]3c3ccc(F)c(F)c3)c(F)c2)n1 |r|
Show InChI
PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
65
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of human Nav1.5 by automated voltage clamp electrophysiology
Citation and Details
Article DOI:
10.1016/j.bmcl.2021.128133
BindingDB Entry DOI:
10.7270/Q2CJ8J7B
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human))
BDBM50568138
(CHEMBL4854735)
Show SMILES
Fc1cccc(NS(=O)(=O)c2cc(F)c(O[C@H]3CCN(CC(F)(F)F)C[C@@H]3c3ccc(F)c(F)c3)c(F)c2)n1 |r|
Show InChI
PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
65
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of human Nav1.5 by automated voltage clamp electrophysiology
Citation and Details
Article DOI:
10.1016/j.bmcl.2021.128133
BindingDB Entry DOI:
10.7270/Q2CJ8J7B
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human))
BDBM50568138
(CHEMBL4854735)
Show SMILES
Fc1cccc(NS(=O)(=O)c2cc(F)c(O[C@H]3CCN(CC(F)(F)F)C[C@@H]3c3ccc(F)c(F)c3)c(F)c2)n1 |r|
Show InChI
PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
110
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of human Nav1.5 by V1/2 protocol based analysis
Citation and Details
Article DOI:
10.1016/j.bmcl.2021.128133
BindingDB Entry DOI:
10.7270/Q2CJ8J7B
More data for this
Ligand-Target Pair
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