Found 3 hits Enz. Inhib. hit(s) with Target = 'Sodium channel protein type 9 subunit alpha' and Ligand = 'BDBM145318' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM145318
(US8952169, 97 | US9771376, Example 97)Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OCC2C3CC4CC(C3)CC2C4)cc1F |TLB:15:16:18:20.21.22,THB:16:24:20:18.17.22,16:17:20:24.23.25,23:24:18:20.21.22,23:21:18:24.16.25,(8.42,2.5,;7.08,1.73,;7.08,.19,;5.75,2.5,;4.98,3.84,;6.52,3.84,;4.42,1.73,;3.08,2.5,;3.08,4.04,;1.75,1.73,;1.75,.19,;.41,-.58,;.41,-2.12,;-.92,.19,;-2.25,-.58,;-3.59,.19,;-4.92,-.58,;-6.25,.19,;-7.58,-.58,;-7.58,-2.12,;-8.42,-4.02,;-7.02,-3.37,;-7,-.97,;-5.82,-4.04,;-4.92,-2.12,;-6.25,-2.89,;-.92,1.73,;.41,2.5,;.41,4.04,)| Show InChI InChI=1S/C20H26ClFN2O4S/c1-24(2)29(26,27)23-20(25)15-8-17(21)19(9-18(15)22)28-10-16-13-4-11-3-12(6-13)7-14(16)5-11/h8-9,11-14,16H,3-7,10H2,1-2H3,(H,23,25) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 7.30 | n/a | n/a | n/a | n/a | n/a | 37 |
Xenon Pharmaceuticals Inc.; Genentech, Inc.
US Patent
| Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all... |
US Patent US8952169 (2015)
BindingDB Entry DOI: 10.7270/Q2M04445 |
More data for this Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM145318
(US8952169, 97 | US9771376, Example 97)Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OCC2C3CC4CC(C3)CC2C4)cc1F |TLB:15:16:18:20.21.22,THB:16:24:20:18.17.22,16:17:20:24.23.25,23:24:18:20.21.22,23:21:18:24.16.25,(8.42,2.5,;7.08,1.73,;7.08,.19,;5.75,2.5,;4.98,3.84,;6.52,3.84,;4.42,1.73,;3.08,2.5,;3.08,4.04,;1.75,1.73,;1.75,.19,;.41,-.58,;.41,-2.12,;-.92,.19,;-2.25,-.58,;-3.59,.19,;-4.92,-.58,;-6.25,.19,;-7.58,-.58,;-7.58,-2.12,;-8.42,-4.02,;-7.02,-3.37,;-7,-.97,;-5.82,-4.04,;-4.92,-2.12,;-6.25,-2.89,;-.92,1.73,;.41,2.5,;.41,4.04,)| Show InChI InChI=1S/C20H26ClFN2O4S/c1-24(2)29(26,27)23-20(25)15-8-17(21)19(9-18(15)22)28-10-16-13-4-11-3-12(6-13)7-14(16)5-11/h8-9,11-14,16H,3-7,10H2,1-2H3,(H,23,25) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 7.30 | n/a | n/a | n/a | n/a | n/a | n/a |
GENENTECH, INC.; XENON PHARMACEUTICALS INC.
US Patent
| Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ... |
US Patent US9771376 (2017)
BindingDB Entry DOI: 10.7270/Q2W0983R |
More data for this Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM145318
(US8952169, 97 | US9771376, Example 97)Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OCC2C3CC4CC(C3)CC2C4)cc1F |TLB:15:16:18:20.21.22,THB:16:24:20:18.17.22,16:17:20:24.23.25,23:24:18:20.21.22,23:21:18:24.16.25,(8.42,2.5,;7.08,1.73,;7.08,.19,;5.75,2.5,;4.98,3.84,;6.52,3.84,;4.42,1.73,;3.08,2.5,;3.08,4.04,;1.75,1.73,;1.75,.19,;.41,-.58,;.41,-2.12,;-.92,.19,;-2.25,-.58,;-3.59,.19,;-4.92,-.58,;-6.25,.19,;-7.58,-.58,;-7.58,-2.12,;-8.42,-4.02,;-7.02,-3.37,;-7,-.97,;-5.82,-4.04,;-4.92,-2.12,;-6.25,-2.89,;-.92,1.73,;.41,2.5,;.41,4.04,)| Show InChI InChI=1S/C20H26ClFN2O4S/c1-24(2)29(26,27)23-20(25)15-8-17(21)19(9-18(15)22)28-10-16-13-4-11-3-12(6-13)7-14(16)5-11/h8-9,11-14,16H,3-7,10H2,1-2H3,(H,23,25) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 51 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Xenon Pharmaceuticals Inc.; Genentech, Inc.
US Patent
| Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac... |
US Patent US8952169 (2015)
BindingDB Entry DOI: 10.7270/Q2M04445 |
More data for this Ligand-Target Pair | |