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Found 1 hit Enz. Inhib. hit(s) with Target = 'Sodium- and chloride-dependent GABA transporter 2' and Ligand = 'BDBM50276014'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium- and chloride-dependent GABA transporter 2


(Mus musculus)		BDBM50276014
PNG
(CHEMBL4125831)
Show SMILES COc1ccc(cc1)C(C#CCN1CCCC(C1)C(O)=O)(c1ccc(OC)cc1)c1ccc2sccc2c1
Show InChI InChI=1S/C32H31NO4S/c1-36-28-11-6-25(7-12-28)32(26-8-13-29(37-2)14-9-26,27-10-15-30-23(21-27)16-20-38-30)17-4-19-33-18-3-5-24(22-33)31(34)35/h6-16,20-21,24H,3,5,18-19,22H2,1-2H3,(H,34,35)
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PC sid
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Similars
Article
PubMed
n/an/a 1.17E+4n/an/an/an/an/an/a



Ludwig-Maximilians-Universit£t M£nchen

Curated by ChEMBL


Assay Description
Inhibition of mouse GAT2 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition mea...

Bioorg Med Chem 26: 3668-3687 (2018)


Article DOI: 10.1016/j.bmc.2018.05.049
BindingDB Entry DOI: 10.7270/Q20004MB
More data for this
Ligand-Target Pair