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Found 1 hit Enz. Inhib. hit(s) with Target = 'Sonic hedgehog protein' and Ligand = 'BDBM50443900'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sonic hedgehog protein


(Mus musculus (Mouse))		BDBM50443900
PNG
(CHEMBL3091568)
Show SMILES CN1CCN(Cc2cccc(NC(=O)c3ccc(Nc4ncc(C)c(n4)-c4ccc(OC(F)(F)F)cc4)cc3)c2)CC1
Show InChI InChI=1S/C31H31F3N6O2/c1-21-19-35-30(38-28(21)23-8-12-27(13-9-23)42-31(32,33)34)37-25-10-6-24(7-11-25)29(41)36-26-5-3-4-22(18-26)20-40-16-14-39(2)15-17-40/h3-13,18-19H,14-17,20H2,1-2H3,(H,36,41)(H,35,37,38)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.30n/an/an/an/an/an/a



Jiangsu Simcere Pharmaceutical Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of SHH signaling pathway in mouse NIH3T3 cells measured after 48 hrs by Gli-luciferase reporter assay

Bioorg Med Chem Lett 23: 6777-83 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.022
BindingDB Entry DOI: 10.7270/Q2R49S7W
More data for this
Ligand-Target Pair