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Found 1 hit Enz. Inhib. hit(s) with Target = 'Sphingomyelin phosphodiesterase' and Ligand = 'BDBM50370156'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sphingomyelin phosphodiesterase


(Homo sapiens)		BDBM50370156
PNG
(CHEMBL4159912)
Show SMILES CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCN(CC)CC)cc1I
Show InChI InChI=1S/C25H29I2NO3/c1-4-7-11-22-24(17-10-8-9-12-21(17)31-22)25(29)18-15-20(27)23(16-19(18)26)30-14-13-28(5-2)6-3/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3
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Article
PubMed
n/an/a 3.98E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of acid sphingomyelinase in human HuH7 cell lysate using NBD-sphingomyelin as substrate after 30 mins by TLC based fluorescence assay

Eur J Med Chem 151: 389-400 (2018)


Article DOI: 10.1016/j.ejmech.2018.03.065
BindingDB Entry DOI: 10.7270/Q21R6T2M
More data for this
Ligand-Target Pair