BindingDB PrimarySearch

Found 7 hits Enz. Inhib. hit(s) with Target = 'Sphingosine 1-phosphate receptor 4' and Ligand = 'BDBM23165'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Sphingosine 1-phosphate receptor 4 (Homo sapiens (Human))	BDBM23165 (CHEMBL366208 \| FTY720-phosphate, (S)-2 \| [(2S)-2-a...) Show SMILES Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	23	-40.5	n/a	n/a	n/a	n/a	n/a	7.5	4
Mitsubishi Pharma Corporation					Assay Description Ki Values were determined by competition of [32P]-S1P binding to stably transfected CHO (S1P1,2,4) or RH7777 (S1P3,5) cells expressing the indicated ...				Bioorg Med Chem 13: 425-32 (2005) Article DOI: 10.1016/j.bmc.2004.10.008 BindingDB Entry DOI: 10.7270/Q257199Q
Mitsubishi Pharma Corporation					More data for this Ligand-Target Pair
Sphingosine 1-phosphate receptor 4 (Homo sapiens (Human))	BDBM23165 (CHEMBL366208 \| FTY720-phosphate, (S)-2 \| [(2S)-2-a...) Show SMILES Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Pharmacology& Toxicology Curated by ChEMBL					Assay Description Agonist activity at human S1P4 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assay				Bioorg Med Chem Lett 22: 553-7 (2011) Article DOI: 10.1016/j.bmcl.2011.10.088 BindingDB Entry DOI: 10.7270/Q2154HGN
Institute of Pharmacology& Toxicology Curated by ChEMBL					More data for this Ligand-Target Pair
Sphingosine 1-phosphate receptor 4 (Homo sapiens (Human))	BDBM23165 (CHEMBL366208 \| FTY720-phosphate, (S)-2 \| [(2S)-2-a...) Show SMILES Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	22.2	n/a	n/a	n/a	n/a
BiogenIdec Inc. Curated by ChEMBL					Assay Description Agonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assay				Bioorg Med Chem Lett 20: 2264-9 (2010) Article DOI: 10.1016/j.bmcl.2010.02.006 BindingDB Entry DOI: 10.7270/Q2JS9QJS
BiogenIdec Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Sphingosine 1-phosphate receptor 4 (Homo sapiens (Human))	BDBM23165 (CHEMBL366208 \| FTY720-phosphate, (S)-2 \| [(2S)-2-a...) Show SMILES Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	22	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at recombinant human S1P4 receptor expressed in Chem-1 cells assessed as calcium flux measured for 180 secs by FLIPR assay				Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00631 BindingDB Entry DOI: 10.7270/Q2D79G4R
TBA					More data for this Ligand-Target Pair
Sphingosine 1-phosphate receptor 4 (Homo sapiens (Human))	BDBM23165 (CHEMBL366208 \| FTY720-phosphate, (S)-2 \| [(2S)-2-a...) Show SMILES Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Agonist activity at human S1P4 expressed in CHO-K1 aequorin cells assessed as calcium accumulation of by luminescence assay in presence of cofactor c...				J Med Chem 54: 6724-33 (2011) Article DOI: 10.1021/jm200609t BindingDB Entry DOI: 10.7270/Q27P8ZSM
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair
Sphingosine 1-phosphate receptor 4 (Homo sapiens (Human))	BDBM23165 (CHEMBL366208 \| FTY720-phosphate, (S)-2 \| [(2S)-2-a...) Show SMILES Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.60	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.8b01695 BindingDB Entry DOI: 10.7270/Q2TQ659P
TBA					More data for this Ligand-Target Pair
Sphingosine 1-phosphate receptor 4 (Homo sapiens (Human))	BDBM23165 (CHEMBL366208 \| FTY720-phosphate, (S)-2 \| [(2S)-2-a...) Show SMILES Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.600	n/a	n/a	7.4	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Agonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]-GTP-gammaS as radioligand				J Med Chem 48: 5373-7 (2005) Article DOI: 10.1021/jm050242f BindingDB Entry DOI: 10.7270/Q218361R
					More data for this Ligand-Target Pair