Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'TGF-beta receptor type-1' and Ligand = 'BDBM50238096'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50238096 (CHEMBL4074485) Show SMILES COc1cccc2nccc(Nc3cc(ncc3C)-c3cccc(C)n3)c12 Show InChI InChI=1S/C22H20N4O/c1-14-13-24-20(16-7-4-6-15(2)25-16)12-19(14)26-18-10-11-23-17-8-5-9-21(27-3)22(17)18/h4-13H,1-3H3,(H,23,24,26)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Curated by ChEMBL					Assay Description Inhibition of recombinant N-terminal GST tagged human ALK5 (200 to 503 residues) expressed in baculovirus expression system using FAM-NH2-KVLTQMGSPSI...				Bioorg Med Chem Lett 27: 1955-1961 (2017) Article DOI: 10.1016/j.bmcl.2017.03.026 BindingDB Entry DOI: 10.7270/Q2QJ7KKZ
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50238096 (CHEMBL4074485) Show SMILES COc1cccc2nccc(Nc3cc(ncc3C)-c3cccc(C)n3)c12 Show InChI InChI=1S/C22H20N4O/c1-14-13-24-20(16-7-4-6-15(2)25-16)12-19(14)26-18-10-11-23-17-8-5-9-21(27-3)22(17)18/h4-13H,1-3H3,(H,23,24,26)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a
Takeda California Curated by ChEMBL					Assay Description Inhibition of ALK5 in human Calu6 cells assessed as reduction in Smad2/3 phosphorylation				Bioorg Med Chem Lett 27: 1955-1961 (2017) Article DOI: 10.1016/j.bmcl.2017.03.026 BindingDB Entry DOI: 10.7270/Q2QJ7KKZ
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50238096 (CHEMBL4074485) Show SMILES COc1cccc2nccc(Nc3cc(ncc3C)-c3cccc(C)n3)c12 Show InChI InChI=1S/C22H20N4O/c1-14-13-24-20(16-7-4-6-15(2)25-16)12-19(14)26-18-10-11-23-17-8-5-9-21(27-3)22(17)18/h4-13H,1-3H3,(H,23,24,26)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	32	n/a	n/a	n/a	n/a
Takeda California Curated by ChEMBL					Assay Description Inhibition of ALK5 (unknown origin) expressed in SBE-bla HEK293T cells assessed as decrease in TGFbeta1-induced Smad2/3 phosphorylation by beta lacta...				Bioorg Med Chem Lett 27: 1955-1961 (2017) Article DOI: 10.1016/j.bmcl.2017.03.026 BindingDB Entry DOI: 10.7270/Q2QJ7KKZ
					More data for this Ligand-Target Pair