Found 2 hits Enz. Inhib. hit(s) with Target = 'TGF-beta receptor type-1 [162-503]' and Ligand = 'BDBM451771' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
TGF-beta receptor type-1 [162-503]
(Homo sapiens (Human)) | BDBM451771
(US10710980, Example 3 | US10947218, Example 3)Show SMILES C[C@@H](N1CC2(COC2)C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:25.28,wD:28.32,1.0,(5.34,-3.47,;5.34,-1.93,;6.67,-1.16,;8.16,-1.55,;8.56,-.07,;10.05,-.46,;10.45,1.02,;8.96,1.42,;7.07,.33,;4.01,-1.16,;2.67,-1.93,;1.34,-1.16,;1.34,.39,;2.67,1.16,;4.01,.39,;.01,1.16,;.01,2.7,;-1.33,3.47,;-2.66,2.7,;-4,3.47,;-2.66,1.16,;-1.33,.39,;-4,.39,;-4,-1.16,;-5.33,1.16,;-6.66,.39,;-6.53,-1.15,;-7.79,-2.03,;-9.19,-1.38,;-10.45,-2.27,;-9.32,.15,;-8.06,1.04,)| Show InChI InChI=1S/C25H32N4O3/c1-16(29-12-25(13-29)14-32-15-25)17-2-4-18(5-3-17)19-10-22(23(26)27-11-19)24(31)28-20-6-8-21(30)9-7-20/h2-5,10-11,16,20-21,30H,6-9,12-15H2,1H3,(H2,26,27)(H,28,31)/t16-,20-,21-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.13E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20... |
US Patent US10947218 (2021)
BindingDB Entry DOI: 10.7270/Q24F1TVV |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1 [162-503]
(Homo sapiens (Human)) | BDBM451771
(US10710980, Example 3 | US10947218, Example 3)Show SMILES C[C@@H](N1CC2(COC2)C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:25.28,wD:28.32,1.0,(5.34,-3.47,;5.34,-1.93,;6.67,-1.16,;8.16,-1.55,;8.56,-.07,;10.05,-.46,;10.45,1.02,;8.96,1.42,;7.07,.33,;4.01,-1.16,;2.67,-1.93,;1.34,-1.16,;1.34,.39,;2.67,1.16,;4.01,.39,;.01,1.16,;.01,2.7,;-1.33,3.47,;-2.66,2.7,;-4,3.47,;-2.66,1.16,;-1.33,.39,;-4,.39,;-4,-1.16,;-5.33,1.16,;-6.66,.39,;-6.53,-1.15,;-7.79,-2.03,;-9.19,-1.38,;-10.45,-2.27,;-9.32,.15,;-8.06,1.04,)| Show InChI InChI=1S/C25H32N4O3/c1-16(29-12-25(13-29)14-32-15-25)17-2-4-18(5-3-17)19-10-22(23(26)27-11-19)24(31)28-20-6-8-21(30)9-7-20/h2-5,10-11,16,20-21,30H,6-9,12-15H2,1H3,(H2,26,27)(H,28,31)/t16-,20-,21-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.13E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (“1... |
US Patent US10710980 (2020)
BindingDB Entry DOI: 10.7270/Q2DF6V81 |
More data for this
Ligand-Target Pair | |
Search and Browse
