BindingDB PrimarySearch

Found 5 hits Enz. Inhib. hit(s) with Target = 'Telomerase reverse transcriptase' and Ligand = 'BDBM50080849'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50080849 (3,6-Bis(3-pyrrolidinopropionamido)acridine \| 3-PYR...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	5.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Ability to inhibit human telomerase in a modified cell-free TRAP assay using extracts from A2780 cell line				Bioorg Med Chem Lett 9: 2463-8 (1999) BindingDB Entry DOI: 10.7270/Q2H41QN7
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50080849 (3,6-Bis(3-pyrrolidinopropionamido)acridine \| 3-PYR...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	5.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Central University of Las Villas Curated by ChEMBL					Assay Description Inhibition of telomerase in human A2780 cells by TRAP assay				Eur J Med Chem 44: 4826-40 (2009) Article DOI: 10.1016/j.ejmech.2009.07.029 BindingDB Entry DOI: 10.7270/Q20R9PHM
Central University of Las Villas Curated by ChEMBL					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50080849 (3,6-Bis(3-pyrrolidinopropionamido)acridine \| 3-PYR...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	5.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibitory activity against Telomerase evaluated by TRAP Assay studies.				J Med Chem 42: 4538-46 (1999) BindingDB Entry DOI: 10.7270/Q2J103VC
Institute of Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50080849 (3,6-Bis(3-pyrrolidinopropionamido)acridine \| 3-PYR...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article	n/a	n/a	5.25E+9	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of telomerase in Homo sapiens (human) A549 cells after 24 hr by TRAP assay				Citation and Details Article DOI: 10.1007/s00044-011-9594-4 BindingDB Entry DOI: 10.7270/Q2X63QV3
TBA					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50080849 (3,6-Bis(3-pyrrolidinopropionamido)acridine \| 3-PYR...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	5.20E+3	n/a	n/a	n/a	n/a
University of London Curated by ChEMBL					Assay Description Inhibitory activity against human telomerase				J Med Chem 46: 4463-76 (2003) Article DOI: 10.1021/jm0308693 BindingDB Entry DOI: 10.7270/Q2RR1XN3
University of London Curated by ChEMBL					More data for this Ligand-Target Pair