Found 2 hits Enz. Inhib. hit(s) with Target = 'Telomeric repeat-binding factor 2-interacting protein 1' and Ligand = 'BDBM50136309' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Telomeric repeat-binding factor 2-interacting protein 1
(Homo sapiens (Human)) | BDBM50136309
(CHEMBL3754122)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(C)=O)[C@@H](C)O)[C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN=[N+]=[N-])C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC#C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C82H138N22O21S2/c1-15-26-53(71(114)98-59(39-44(3)4)77(120)100-62(43-105)68(85)111)92-72(115)55(29-20-23-34-83)95-78(121)61(41-52-27-18-17-19-28-52)97-69(112)47(8)89-70(113)54(31-22-25-36-88-104-86)93-73(116)56(30-21-24-35-84)94-76(119)60(40-45(5)6)99-80(123)66(49(10)107)102-75(118)58(33-38-127-14)96-74(117)57(32-37-126-13)91-63(110)42-87-79(122)64(46(7)16-2)101-82(125)67(50(11)108)103-81(124)65(48(9)106)90-51(12)109/h1,17-19,27-28,44-50,53-62,64-67,105-108H,16,20-26,29-43,83-84H2,2-14H3,(H2,85,111)(H,87,122)(H,89,113)(H,90,109)(H,91,110)(H,92,115)(H,93,116)(H,94,119)(H,95,121)(H,96,117)(H,97,112)(H,98,114)(H,99,123)(H,100,120)(H,101,125)(H,102,118)(H,103,124)/t46-,47-,48+,49+,50+,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,64-,65-,66-,67-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Competitive binding to RAP1 (unknown origin) incubated for 1 hr by fluorescence polarization-based binding assay |
J Med Chem 59: 328-34 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01465
BindingDB Entry DOI: 10.7270/Q2MP553D |
More data for this
Ligand-Target Pair | |
Telomeric repeat-binding factor 2-interacting protein 1
(Homo sapiens (Human)) | BDBM50136309
(CHEMBL3754122)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(C)=O)[C@@H](C)O)[C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN=[N+]=[N-])C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC#C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C82H138N22O21S2/c1-15-26-53(71(114)98-59(39-44(3)4)77(120)100-62(43-105)68(85)111)92-72(115)55(29-20-23-34-83)95-78(121)61(41-52-27-18-17-19-28-52)97-69(112)47(8)89-70(113)54(31-22-25-36-88-104-86)93-73(116)56(30-21-24-35-84)94-76(119)60(40-45(5)6)99-80(123)66(49(10)107)102-75(118)58(33-38-127-14)96-74(117)57(32-37-126-13)91-63(110)42-87-79(122)64(46(7)16-2)101-82(125)67(50(11)108)103-81(124)65(48(9)106)90-51(12)109/h1,17-19,27-28,44-50,53-62,64-67,105-108H,16,20-26,29-43,83-84H2,2-14H3,(H2,85,111)(H,87,122)(H,89,113)(H,90,109)(H,91,110)(H,92,115)(H,93,116)(H,94,119)(H,95,121)(H,96,117)(H,97,112)(H,98,114)(H,99,123)(H,100,120)(H,101,125)(H,102,118)(H,103,124)/t46-,47-,48+,49+,50+,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,64-,65-,66-,67-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 9.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Competitive binding to RAP1 (unknown origin) incubated for 1 hr by fluorescence polarization-based binding assay |
J Med Chem 59: 328-34 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01465
BindingDB Entry DOI: 10.7270/Q2MP553D |
More data for this
Ligand-Target Pair | |
Search and Browse
