Found 2 hits Enz. Inhib. hit(s) with Target = 'Telomeric repeat-binding factor 2-interacting protein 1' and Ligand = 'BDBM50136314' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Telomeric repeat-binding factor 2-interacting protein 1
(Homo sapiens (Human)) | BDBM50136314
(CHEMBL3752069)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(C)=O)[C@@H](C)O)[C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C78H135N19O22S2/c1-16-41(6)59(94-78(119)63(47(12)102)97-77(118)60(44(9)99)85-48(13)103)74(115)82-37-58(104)86-52(28-32-120-14)68(109)89-53(29-33-121-15)70(111)96-62(46(11)101)76(117)91-54(34-39(2)3)71(112)87-50(26-20-22-30-79)67(108)84-42(7)65(106)83-43(8)66(107)90-56(36-49-24-18-17-19-25-49)73(114)88-51(27-21-23-31-80)69(110)95-61(45(10)100)75(116)92-55(35-40(4)5)72(113)93-57(38-98)64(81)105/h17-19,24-25,39-47,50-57,59-63,98-102H,16,20-23,26-38,79-80H2,1-15H3,(H2,81,105)(H,82,115)(H,83,106)(H,84,108)(H,85,103)(H,86,104)(H,87,112)(H,88,114)(H,89,109)(H,90,107)(H,91,117)(H,92,116)(H,93,113)(H,94,119)(H,95,110)(H,96,111)(H,97,118)/t41-,42-,43-,44+,45+,46+,47+,50-,51-,52-,53-,54-,55-,56-,57-,59-,60-,61-,62-,63-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Competitive binding to RAP1 (unknown origin) incubated for 1 hr by fluorescence polarization-based binding assay |
J Med Chem 59: 328-34 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01465
BindingDB Entry DOI: 10.7270/Q2MP553D |
More data for this
Ligand-Target Pair | |
Telomeric repeat-binding factor 2-interacting protein 1
(Homo sapiens (Human)) | BDBM50136314
(CHEMBL3752069)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(C)=O)[C@@H](C)O)[C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C78H135N19O22S2/c1-16-41(6)59(94-78(119)63(47(12)102)97-77(118)60(44(9)99)85-48(13)103)74(115)82-37-58(104)86-52(28-32-120-14)68(109)89-53(29-33-121-15)70(111)96-62(46(11)101)76(117)91-54(34-39(2)3)71(112)87-50(26-20-22-30-79)67(108)84-42(7)65(106)83-43(8)66(107)90-56(36-49-24-18-17-19-25-49)73(114)88-51(27-21-23-31-80)69(110)95-61(45(10)100)75(116)92-55(35-40(4)5)72(113)93-57(38-98)64(81)105/h17-19,24-25,39-47,50-57,59-63,98-102H,16,20-23,26-38,79-80H2,1-15H3,(H2,81,105)(H,82,115)(H,83,106)(H,84,108)(H,85,103)(H,86,104)(H,87,112)(H,88,114)(H,89,109)(H,90,107)(H,91,117)(H,92,116)(H,93,113)(H,94,119)(H,95,110)(H,96,111)(H,97,118)/t41-,42-,43-,44+,45+,46+,47+,50-,51-,52-,53-,54-,55-,56-,57-,59-,60-,61-,62-,63-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description
Competitive binding to RAP1 (unknown origin) incubated for 1 hr by fluorescence polarization-based binding assay |
J Med Chem 59: 328-34 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01465
BindingDB Entry DOI: 10.7270/Q2MP553D |
More data for this
Ligand-Target Pair | |
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