Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tissue-type plasminogen activator' and Ligand = 'BDBM50088980'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM50088980 (CHEMBL177745 | {(R)-1-[(S)-1-((S)-1-Carbamimidoyl-...) Show SMILES C[C@H](NC(=O)[C@@](C)(CO)NC(=O)OCc1ccccc1)C(=O)N[C@H]1CCCN(C1O)C(N)=N Show InChI InChI=1S/C21H32N6O6/c1-13(16(29)25-15-9-6-10-27(17(15)30)19(22)23)24-18(31)21(2,12-28)26-20(32)33-11-14-7-4-3-5-8-14/h3-5,7-8,13,15,17,28,30H,6,9-12H2,1-2H3,(H3,22,23)(H,24,31)(H,25,29)(H,26,32)/t13-,15-,17?,21+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Corvas International, Inc. Curated by ChEMBL					Assay Description The compound was tested in vitro for its inhibitory activity against human t-PA enzyme, activity expressed as IC50				Bioorg Med Chem Lett 10: 983-7 (2000) BindingDB Entry DOI: 10.7270/Q2765DKB
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