Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tissue-type plasminogen activator' and Ligand = 'BDBM50088985'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM50088985 (CHEMBL369042 | {2-[2-(1-Carbamimidoyl-2-hydroxy-pi...) Show SMILES NC(=N)N1CCCC(NC(=O)[C@H]2CCCN2C(=O)C(CO)NC(=O)OCc2ccccc2)C1O Show InChI InChI=1S/C22H32N6O6/c23-21(24)28-11-4-8-15(19(28)31)25-18(30)17-9-5-10-27(17)20(32)16(12-29)26-22(33)34-13-14-6-2-1-3-7-14/h1-3,6-7,15-17,19,29,31H,4-5,8-13H2,(H3,23,24)(H,25,30)(H,26,33)/t15?,16?,17-,19?/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Corvas International, Inc. Curated by ChEMBL					Assay Description The compound was tested in vitro for its inhibitory activity against human t-PA enzyme, activity expressed as IC50				Bioorg Med Chem Lett 10: 983-7 (2000) BindingDB Entry DOI: 10.7270/Q2765DKB
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