Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Transient receptor potential M8 protein' and Ligand = 'BDBM241631'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential M8 protein (Canis lupus familiaris (Dog))	BDBM241631 (US9409915, 14 | US9718820, Compound 14) Show SMILES CC(C)Oc1nc(cc2nc([nH]c12)-c1c(C#N)c(nn1C)C(C)(C)C)-c1ccccc1C(F)(F)F Show InChI InChI=1S/C25H25F3N6O/c1-13(2)35-23-19-18(11-17(31-23)14-9-7-8-10-16(14)25(26,27)28)30-22(32-19)20-15(12-29)21(24(3,4)5)33-34(20)6/h7-11,13H,1-6H3,(H,30,32)	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	25
JANSSEN PHARMACEUTICA NV US Patent					Assay Description HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, ...				US Patent US9718820 (2017) BindingDB Entry DOI: 10.7270/Q2RV0QQ5
					More data for this Ligand-Target Pair
Transient receptor potential M8 protein (Canis lupus familiaris (Dog))	BDBM241631 (US9409915, 14 | US9718820, Compound 14) Show SMILES CC(C)Oc1nc(cc2nc([nH]c12)-c1c(C#N)c(nn1C)C(C)(C)C)-c1ccccc1C(F)(F)F Show InChI InChI=1S/C25H25F3N6O/c1-13(2)35-23-19-18(11-17(31-23)14-9-7-8-10-16(14)25(26,27)28)30-22(32-19)20-15(12-29)21(24(3,4)5)33-34(20)6/h7-11,13H,1-6H3,(H,30,32)	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	37
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...				US Patent US9409915 (2016) BindingDB Entry DOI: 10.7270/Q23J3BVJ
					More data for this Ligand-Target Pair