Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human)) | BDBM50164168 (1,3,4-Eugenol | 1-Hydroxy-2-methoxy-4-allylbenzene...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.61E+5 | n/a | n/a | n/a | n/a |
University of Hull Curated by ChEMBL | Assay Description Agonist activity at human TRPA1 expressed in HEK293 assessed as increase in calcium influx by two electrode voltage clamp method | Eur J Med Chem 170: 141-156 (2019) Article DOI: 10.1016/j.ejmech.2019.02.074 BindingDB Entry DOI: 10.7270/Q2F76GWS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human)) | BDBM50164168 (1,3,4-Eugenol | 1-Hydroxy-2-methoxy-4-allylbenzene...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.16E+5 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at TRPA1 (unknown origin) by calcium imaging assay | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127639 BindingDB Entry DOI: 10.7270/Q2S46WKS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human)) | BDBM50164168 (1,3,4-Eugenol | 1-Hydroxy-2-methoxy-4-allylbenzene...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.68E+5 | n/a | n/a | n/a | n/a |
University of Hull Curated by ChEMBL | Assay Description Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay | Eur J Med Chem 170: 141-156 (2019) Article DOI: 10.1016/j.ejmech.2019.02.074 BindingDB Entry DOI: 10.7270/Q2F76GWS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human)) | BDBM50164168 (1,3,4-Eugenol | 1-Hydroxy-2-methoxy-4-allylbenzene...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.70E+5 | n/a | n/a | n/a | n/a |
University of Hull Curated by ChEMBL | Assay Description Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay | Eur J Med Chem 170: 141-156 (2019) Article DOI: 10.1016/j.ejmech.2019.02.074 BindingDB Entry DOI: 10.7270/Q2F76GWS | |||||||||||
More data for this Ligand-Target Pair |