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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Transient receptor potential cation channel subfamily M member 8' and Ligand = 'BDBM50442420'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50442420
PNG
(CHEMBL2443065)
Show SMILES FC(F)(F)c1csc(NC(=O)N2CCC3(CC2)CCc2cccc(Cl)c2O3)n1
Show InChI InChI=1S/C18H17ClF3N3O2S/c19-12-3-1-2-11-4-5-17(27-14(11)12)6-8-25(9-7-17)16(26)24-15-23-13(10-28-15)18(20,21)22/h1-3,10H,4-9H2,(H,23,24,26)
PDB

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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 266n/an/an/an/an/an/a



Glenmark Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced 45Ca2+ uptake incubated for 10 mins prior to icili...

Bioorg Med Chem 21: 6542-53 (2013)


Article DOI: 10.1016/j.bmc.2013.08.031
BindingDB Entry DOI: 10.7270/Q2TH8P5S
More data for this
Ligand-Target Pair