Compile Data Set for Download or QSAR

Found 5 hits Enz. Inhib. hit(s) with Target = 'Transient receptor potential cation channel subfamily V member 1' and Ligand = 'BDBM50332846'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50332846 (2-(4-isobutylpiperazin-1-yl)-N-(4-(trifluoromethyl...) Show SMILES CC(C)CN1CCN(CC1)c1nc2CCN(CCc2c(Nc2ccc(cc2)C(F)(F)F)n1)c1ncccc1C(F)(F)F Show InChI InChI=1S/C29H33F6N7/c1-19(2)18-40-14-16-42(17-15-40)27-38-24-10-13-41(26-23(29(33,34)35)4-3-11-36-26)12-9-22(24)25(39-27)37-21-7-5-20(6-8-21)28(30,31)32/h3-8,11,19H,9-10,12-18H2,1-2H3,(H,37,38,39)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research and Development LLC Curated by ChEMBL					Assay Description Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ level by FLIPR assay				Bioorg Med Chem Lett 20: 7142-6 (2010) Article DOI: 10.1016/j.bmcl.2010.09.006 BindingDB Entry DOI: 10.7270/Q26Q1XH0
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50332846 (2-(4-isobutylpiperazin-1-yl)-N-(4-(trifluoromethyl...) Show SMILES CC(C)CN1CCN(CC1)c1nc2CCN(CCc2c(Nc2ccc(cc2)C(F)(F)F)n1)c1ncccc1C(F)(F)F Show InChI InChI=1S/C29H33F6N7/c1-19(2)18-40-14-16-42(17-15-40)27-38-24-10-13-41(26-23(29(33,34)35)4-3-11-36-26)12-9-22(24)25(39-27)37-21-7-5-20(6-8-21)28(30,31)32/h3-8,11,19H,9-10,12-18H2,1-2H3,(H,37,38,39)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research and Development LLC Curated by ChEMBL					Assay Description Inhibition of rat TRPV1 expressed in HEK cells				Bioorg Med Chem Lett 20: 7142-6 (2010) Article DOI: 10.1016/j.bmcl.2010.09.006 BindingDB Entry DOI: 10.7270/Q26Q1XH0
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50332846 (2-(4-isobutylpiperazin-1-yl)-N-(4-(trifluoromethyl...) Show SMILES CC(C)CN1CCN(CC1)c1nc2CCN(CCc2c(Nc2ccc(cc2)C(F)(F)F)n1)c1ncccc1C(F)(F)F Show InChI InChI=1S/C29H33F6N7/c1-19(2)18-40-14-16-42(17-15-40)27-38-24-10-13-41(26-23(29(33,34)35)4-3-11-36-26)12-9-22(24)25(39-27)37-21-7-5-20(6-8-21)28(30,31)32/h3-8,11,19H,9-10,12-18H2,1-2H3,(H,37,38,39)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	67	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research and Development LLC Curated by ChEMBL					Assay Description Inhibition of human TRPV1 expressed in HEK cells				Bioorg Med Chem Lett 20: 7142-6 (2010) Article DOI: 10.1016/j.bmcl.2010.09.006 BindingDB Entry DOI: 10.7270/Q26Q1XH0
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50332846 (2-(4-isobutylpiperazin-1-yl)-N-(4-(trifluoromethyl...) Show SMILES CC(C)CN1CCN(CC1)c1nc2CCN(CCc2c(Nc2ccc(cc2)C(F)(F)F)n1)c1ncccc1C(F)(F)F Show InChI InChI=1S/C29H33F6N7/c1-19(2)18-40-14-16-42(17-15-40)27-38-24-10-13-41(26-23(29(33,34)35)4-3-11-36-26)12-9-22(24)25(39-27)37-21-7-5-20(6-8-21)28(30,31)32/h3-8,11,19H,9-10,12-18H2,1-2H3,(H,37,38,39)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	89	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research and Development LLC Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ level by FLIPR assay				Bioorg Med Chem Lett 20: 7142-6 (2010) Article DOI: 10.1016/j.bmcl.2010.09.006 BindingDB Entry DOI: 10.7270/Q26Q1XH0
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50332846 (2-(4-isobutylpiperazin-1-yl)-N-(4-(trifluoromethyl...) Show SMILES CC(C)CN1CCN(CC1)c1nc2CCN(CCc2c(Nc2ccc(cc2)C(F)(F)F)n1)c1ncccc1C(F)(F)F Show InChI InChI=1S/C29H33F6N7/c1-19(2)18-40-14-16-42(17-15-40)27-38-24-10-13-41(26-23(29(33,34)35)4-3-11-36-26)12-9-22(24)25(39-27)37-21-7-5-20(6-8-21)28(30,31)32/h3-8,11,19H,9-10,12-18H2,1-2H3,(H,37,38,39)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	330	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research and Development LLC Curated by ChEMBL					Assay Description Displacement of [3H]RTX from rat TRPV1 expressed in HEK cells				Bioorg Med Chem Lett 20: 7142-6 (2010) Article DOI: 10.1016/j.bmcl.2010.09.006 BindingDB Entry DOI: 10.7270/Q26Q1XH0
					More data for this Ligand-Target Pair