Found 6 hits Enz. Inhib. hit(s) with Target = 'Transient receptor potential cation channel subfamily V member 1' and Ligand = 'BDBM50372585' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50372585
(CHEMBL404165)Show SMILES OC1CCc2cccc(Nc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)c2C1 |w:1.0| Show InChI InChI=1S/C21H18F3N3O/c22-21(23,24)15-7-4-14(5-8-15)19-11-20(26-12-25-19)27-18-3-1-2-13-6-9-16(28)10-17(13)18/h1-5,7-8,11-12,16,28H,6,9-10H2,(H,25,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.580 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium mobilization |
Bioorg Med Chem Lett 18: 1830-4 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.022
BindingDB Entry DOI: 10.7270/Q2FB53SJ |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50372585
(CHEMBL404165)Show SMILES OC1CCc2cccc(Nc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)c2C1 |w:1.0| Show InChI InChI=1S/C21H18F3N3O/c22-21(23,24)15-7-4-14(5-8-15)19-11-20(26-12-25-19)27-18-3-1-2-13-6-9-16(28)10-17(13)18/h1-5,7-8,11-12,16,28H,6,9-10H2,(H,25,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.620 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium mobilization |
Bioorg Med Chem Lett 18: 1830-4 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.022
BindingDB Entry DOI: 10.7270/Q2FB53SJ |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50372585
(CHEMBL404165)Show SMILES OC1CCc2cccc(Nc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)c2C1 |w:1.0| Show InChI InChI=1S/C21H18F3N3O/c22-21(23,24)15-7-4-14(5-8-15)19-11-20(26-12-25-19)27-18-3-1-2-13-6-9-16(28)10-17(13)18/h1-5,7-8,11-12,16,28H,6,9-10H2,(H,25,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.650 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium mobilization |
Bioorg Med Chem Lett 18: 1830-4 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.022
BindingDB Entry DOI: 10.7270/Q2FB53SJ |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50372585
(CHEMBL404165)Show SMILES OC1CCc2cccc(Nc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)c2C1 |w:1.0| Show InChI InChI=1S/C21H18F3N3O/c22-21(23,24)15-7-4-14(5-8-15)19-11-20(26-12-25-19)27-18-3-1-2-13-6-9-16(28)10-17(13)18/h1-5,7-8,11-12,16,28H,6,9-10H2,(H,25,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium mobilization |
Bioorg Med Chem Lett 18: 1830-4 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.022
BindingDB Entry DOI: 10.7270/Q2FB53SJ |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50372585
(CHEMBL404165)Show SMILES OC1CCc2cccc(Nc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)c2C1 |w:1.0| Show InChI InChI=1S/C21H18F3N3O/c22-21(23,24)15-7-4-14(5-8-15)19-11-20(26-12-25-19)27-18-3-1-2-13-6-9-16(28)10-17(13)18/h1-5,7-8,11-12,16,28H,6,9-10H2,(H,25,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium mobilization |
Bioorg Med Chem Lett 18: 1830-4 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.022
BindingDB Entry DOI: 10.7270/Q2FB53SJ |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50372585
(CHEMBL404165)Show SMILES OC1CCc2cccc(Nc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)c2C1 |w:1.0| Show InChI InChI=1S/C21H18F3N3O/c22-21(23,24)15-7-4-14(5-8-15)19-11-20(26-12-25-19)27-18-3-1-2-13-6-9-16(28)10-17(13)18/h1-5,7-8,11-12,16,28H,6,9-10H2,(H,25,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium mobilization |
Bioorg Med Chem Lett 18: 1830-4 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.022
BindingDB Entry DOI: 10.7270/Q2FB53SJ |
More data for this
Ligand-Target Pair | |
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