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Found 1 hit Enz. Inhib. hit(s) with Target = 'Tryptase beta-2/delta/gamma' and Ligand = 'BDBM50093195'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tryptase beta-2/delta/gamma


(Homo sapiens (Human))		BDBM50093195
PNG
(CHEMBL80502 | Derivative of piperazine-1-carboxyli...)
Show SMILES [#7]\[#6](-[#7])=[#7]/c1ccc(-[#6]-[#7]-[#6](=O)-[#7]-2-[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#8]-[#6@@H]-2-[#6]-[#6]-[#6]-[#6@@H](-[#6]-[#6]-[#6]-2)-[#8]-[#6](=O)-[#7]-2-[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-[#6]-[#6]-[#6]-n2ccnc2)cc1
Show InChI InChI=1S/C35H52N10O6/c36-32(37)40-28-12-10-27(11-13-28)25-39-33(47)43-19-23-45(24-20-43)35(49)51-30-7-3-5-29(6-4-8-30)50-34(48)44-21-17-42(18-22-44)31(46)9-1-2-15-41-16-14-38-26-41/h10-14,16,26,29-30H,1-9,15,17-25H2,(H,39,47)(H4,36,37,40)/t29-,30+
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PubMed
 1.00E+3n/an/an/an/an/an/an/an/a



Axys Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Evaluated for its inhibitory potency against tryptase

Bioorg Med Chem Lett 10: 2361-6 (2001)


BindingDB Entry DOI: 10.7270/Q2HX1BWR
More data for this
Ligand-Target Pair