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Found 1 hit Enz. Inhib. hit(s) with Target = 'Tubulin beta-3 chain' and Ligand = 'BDBM50493264'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tubulin beta-3 chain


(Homo sapiens)		BDBM50493264
PNG
(CHEMBL1824506)
Show SMILES Cl.COc1ccc(cc1)N(C)c1nc(C)nc2CC(C)Cc12
Show InChI InChI=1S/C17H21N3O.ClH/c1-11-9-15-16(10-11)18-12(2)19-17(15)20(3)13-5-7-14(21-4)8-6-13;/h5-8,11H,9-10H2,1-4H3;1H
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n/an/a 24n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibition of beta3 tubulin overexpressed in human HeLa cells after 48 hrs by SRB assay

J Med Chem 56: 6829-44 (2013)


Article DOI: 10.1021/jm400639z
BindingDB Entry DOI: 10.7270/Q2Z60S0W
More data for this
Ligand-Target Pair