BindingDB PrimarySearch

Found 25 hits Enz. Inhib. hit(s) with Target = 'Type-1 angiotensin II receptor' and Ligand = 'BDBM82258'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Type-1 angiotensin II receptor (Homo sapiens (Human))	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravance Biopharma US Inc. Curated by ChEMBL					Assay Description Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA				ACS Med Chem Lett 10: 86-91 (2019) Article DOI: 10.1021/acsmedchemlett.8b00462 BindingDB Entry DOI: 10.7270/Q2D50R6V
Theravance Biopharma US Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (Homo sapiens (Human))	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars		11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (Homo sapiens (Human))	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 re...				J Med Chem 59: 1925-45 (2016) Article DOI: 10.1021/acs.jmedchem.5b01495 BindingDB Entry DOI: 10.7270/Q2V69MGK
University of Regensburg Curated by ChEMBL					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (Homo sapiens (Human))	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	17	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Displacement of [3H]-Angiotensin 2 from AT1 receptor in human PLC/PRF/5 cells after 20 mins by liquid scintillation counting				J Med Chem 59: 1925-45 (2016) Article DOI: 10.1021/acs.jmedchem.5b01495 BindingDB Entry DOI: 10.7270/Q2V69MGK
University of Regensburg Curated by ChEMBL					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (Homo sapiens (Human))	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.330	n/a	n/a	n/a	n/a	n/a	n/a
School of Chemical Engineering& the Environment Curated by ChEMBL					Assay Description Inhibition of angiotensin AT1 receptor				Bioorg Med Chem 20: 4208-16 (2012) Article DOI: 10.1016/j.bmc.2012.05.056 BindingDB Entry DOI: 10.7270/Q2GT5P7J
					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (RABBIT)	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic rings				Bioorg Med Chem Lett 4: 1297-1302 (1994) Article DOI: 10.1016/S0960-894X(01)80348-6 BindingDB Entry DOI: 10.7270/Q2G44QRD
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (Homo sapiens (Human))	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
National Hellenic Research Foundation Curated by ChEMBL					Assay Description Displacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting method				Bioorg Med Chem 24: 4444-4451 (2016) Article DOI: 10.1016/j.bmc.2016.07.047 BindingDB Entry DOI: 10.7270/Q20P11ZV
National Hellenic Research Foundation Curated by ChEMBL					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (Homo sapiens (Human))	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.60	n/a	n/a	n/a	n/a	n/a	n/a
University of Patras Curated by ChEMBL					Assay Description Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis				Eur J Med Chem 62: 352-70 (2013) Article DOI: 10.1016/j.ejmech.2012.12.044 BindingDB Entry DOI: 10.7270/Q2DF6V47
University of Patras Curated by ChEMBL					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (Homo sapiens (Human))	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.62	n/a	n/a	n/a	n/a	n/a	n/a
University of Patras Curated by ChEMBL					Assay Description Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting				Eur J Med Chem 55: 358-74 (2012) Article DOI: 10.1016/j.ejmech.2012.07.040 BindingDB Entry DOI: 10.7270/Q23B617T
University of Patras Curated by ChEMBL					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (Homo sapiens (Human))	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
University of Patras Curated by ChEMBL					Assay Description Displacement of 125[I-Sar1-Ile8]ANG II from human AT1 receptor expressed in HEK293 membranes after 1 hr by gamma counting				Eur J Med Chem 55: 358-74 (2012) Article DOI: 10.1016/j.ejmech.2012.07.040 BindingDB Entry DOI: 10.7270/Q23B617T
University of Patras Curated by ChEMBL					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (Homo sapiens (Human))	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars		n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (Homo sapiens (Human))	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Beijing Institute of Technology Curated by ChEMBL					Assay Description Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis				Eur J Med Chem 69: 44-54 (2013) Article DOI: 10.1016/j.ejmech.2013.08.014 BindingDB Entry DOI: 10.7270/Q2PK0K32
Beijing Institute of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (Homo sapiens (Human))	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	16.2	n/a	n/a	n/a	n/a	n/a	n/a
Beijing Institute of Technology Curated by ChEMBL					Assay Description Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma counting				Eur J Med Chem 49: 183-90 (2012) Article DOI: 10.1016/j.ejmech.2012.01.009 BindingDB Entry DOI: 10.7270/Q29K4BPW
Beijing Institute of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (Homo sapiens (Human))	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	16.2	n/a	n/a	n/a	n/a	n/a	n/a
School of Chemical Engineering& the Environment Curated by ChEMBL					Assay Description Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting				Bioorg Med Chem 20: 4208-16 (2012) Article DOI: 10.1016/j.bmc.2012.05.056 BindingDB Entry DOI: 10.7270/Q2GT5P7J
					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (Homo sapiens (Human))	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Beijing Institute of Technology Curated by ChEMBL					Assay Description Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins				Eur J Med Chem 103: 473-87 (2015) Article DOI: 10.1016/j.ejmech.2015.09.010 BindingDB Entry DOI: 10.7270/Q21J9DS4
Beijing Institute of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (RABBIT)	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1039/d2md00206j BindingDB Entry DOI: 10.7270/Q2PC36F2
TBA					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (RABBIT)	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	61.1	n/a	n/a	n/a	n/a	n/a	n/a
Kyung Hee University Curated by ChEMBL					Assay Description Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensi...				Bioorg Med Chem Lett 22: 1649-54 (2012) Article DOI: 10.1016/j.bmcl.2011.12.116 BindingDB Entry DOI: 10.7270/Q22R3S48
Kyung Hee University Curated by ChEMBL					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (Bos taurus)	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	95	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex				Bioorg Med Chem 20: 4661-7 (2012) Article DOI: 10.1016/j.bmc.2012.06.011 BindingDB Entry DOI: 10.7270/Q2G73FS6
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (Homo sapiens (Human))	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
University of Basel Curated by ChEMBL					Assay Description Inhibition of ATR1 (unknown origin)				J Med Chem 62: 8915-8930 (2019) Article DOI: 10.1021/acs.jmedchem.9b00179 BindingDB Entry DOI: 10.7270/Q2377CZQ
University of Basel Curated by ChEMBL					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (RABBIT)	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	12.6	n/a	n/a	n/a	n/a	n/a
Beijing Institute of Technology Curated by ChEMBL					Assay Description Antagonist activity at angiotensin 2 AT1 receptor in Japanese White rabbits thoracic aorta assessed as inhibition of KCl-indcuced contraction after 6...				Eur J Med Chem 49: 183-90 (2012) Article DOI: 10.1016/j.ejmech.2012.01.009 BindingDB Entry DOI: 10.7270/Q29K4BPW
Beijing Institute of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (RABBIT)	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	12.6	n/a	n/a	n/a	n/a	n/a
The M. S. University of Baroda Curated by ChEMBL					Assay Description Antagonist activity at angiotensin AT1 receptor in rabbit thoracic aortic rings				Bioorg Med Chem 18: 8418-56 (2010) Article DOI: 10.1016/j.bmc.2010.10.043 BindingDB Entry DOI: 10.7270/Q2H70G3T
The M. S. University of Baroda Curated by ChEMBL					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (RABBIT)	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	n/a	1.58	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro binding affinity against Angiotensin II receptor in rabbit aorta rings				Bioorg Med Chem Lett 4: 87-92 (1994) Article DOI: 10.1016/S0960-894X(01)81127-6 BindingDB Entry DOI: 10.7270/Q2BC40QF
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (RABBIT)	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	12.6	n/a	n/a	n/a	n/a	n/a
School of Chemical Engineering& the Environment Curated by ChEMBL					Assay Description Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post ...				Bioorg Med Chem 20: 4208-16 (2012) Article DOI: 10.1016/j.bmc.2012.05.056 BindingDB Entry DOI: 10.7270/Q2GT5P7J
					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (RABBIT)	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	n/a	3.72	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description pA2 value determined in vitro against angiotensin II receptor, type 1 using rabbit aortic rings				Bioorg Med Chem Lett 4: 173-176 (1994) Article DOI: 10.1016/S0960-894X(01)81142-2 BindingDB Entry DOI: 10.7270/Q2G44RFS
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor (RABBIT)	BDBM82258 (CAS_114798-26-4 \| Losartan \| NSC_3961) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a
Universit£ di Siena Curated by ChEMBL					Assay Description Antagonist activity at AT1 receptor in KCl-contracted rabbit aortic strips after 60 mins				J Med Chem 51: 2137-46 (2008) Article DOI: 10.1021/jm7011563 BindingDB Entry DOI: 10.7270/Q20P10X0
Universit£ di Siena Curated by ChEMBL					More data for this Ligand-Target Pair