Found 3 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase ABL1' and Ligand = 'BDBM50490895' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Tyrosine-protein kinase ABL1
(Homo sapiens (Human)) | BDBM50490895
(CHEMBL2347711)Show InChI InChI=1S/C18H19N3O2S/c1-3-19-17(22)21-18-20-14-10-9-12(11-16(14)24-18)13-7-5-6-8-15(13)23-4-2/h5-11H,3-4H2,1-2H3,(H2,19,20,21,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 0.0300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase ABL1
(Homo sapiens (Human)) | BDBM50490895
(CHEMBL2347711)Show InChI InChI=1S/C18H19N3O2S/c1-3-19-17(22)21-18-20-14-10-9-12(11-16(14)24-18)13-7-5-6-8-15(13)23-4-2/h5-11H,3-4H2,1-2H3,(H2,19,20,21,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 0.0640 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase ABL1
(Homo sapiens (Human)) | BDBM50490895
(CHEMBL2347711)Show InChI InChI=1S/C18H19N3O2S/c1-3-19-17(22)21-18-20-14-10-9-12(11-16(14)24-18)13-7-5-6-8-15(13)23-4-2/h5-11H,3-4H2,1-2H3,(H2,19,20,21,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.0640 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Inhibition of breakpoint cluster region-Abelson tyrosine kinase T315I mutant (unknown origin) using [gamma-33P]ATP as substrate by radiometric kinase... |
J Med Chem 56: 3531-45 (2013)
Article DOI: 10.1021/jm301891t BindingDB Entry DOI: 10.7270/Q2BG2RW2 |
More data for this Ligand-Target Pair | |