Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK' and Ligand = 'BDBM149469'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM149469 (US8975260, 116) Show SMILES CC(C)(C)c1cc2CN(C(=O)c2s1)c1nc(ccc1F)-c1cc(Nc2cc([nH]n2)C2CC2)c(=O)[nH]n1 Show InChI InChI=1S/C25H24FN7O2S/c1-25(2,3)19-8-13-11-33(24(35)21(13)36-19)22-14(26)6-7-15(28-22)17-9-18(23(34)32-30-17)27-20-10-16(29-31-20)12-4-5-12/h6-10,12H,4-5,11H2,1-3H3,(H,32,34)(H2,27,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	35	n/a	n/a	n/a	n/a	7.5	n/a
Genetech, Inc; Gilead Connecticut, Inc. US Patent					Assay Description A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus Bt...				US Patent US8975260 (2015) BindingDB Entry DOI: 10.7270/Q2PK0DW9
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