Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK' and Ligand = 'BDBM149470'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM149470 (US8975260, 117) Show SMILES Cc1cc(Nc2cc(n[nH]c2=O)-c2ccc(F)c(n2)N2Cc3cc(sc3C2=O)C(C)(C)C)nn1C Show InChI InChI=1S/C24H24FN7O2S/c1-12-8-19(30-31(12)5)26-17-10-16(28-29-22(17)33)15-7-6-14(25)21(27-15)32-11-13-9-18(24(2,3)4)35-20(13)23(32)34/h6-10H,11H2,1-5H3,(H,29,33)(H,26,28,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	45	n/a	n/a	n/a	n/a	7.5	n/a
Genetech, Inc; Gilead Connecticut, Inc. US Patent					Assay Description A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus Bt...				US Patent US8975260 (2015) BindingDB Entry DOI: 10.7270/Q2PK0DW9
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