Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK' and Ligand = 'BDBM149472'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM149472 (US8975260, 119) Show SMILES Cc1c(cccc1-c1cc(Nc2cc(CN3CC(F)(F)C3)n(C)n2)c(=O)[nH]n1)N1Cc2cc(sc2C1=O)C(C)(C)C Show InChI InChI=1S/C29H31F2N7O2S/c1-16-19(7-6-8-22(16)38-12-17-9-23(28(2,3)4)41-25(17)27(38)40)20-11-21(26(39)34-33-20)32-24-10-18(36(5)35-24)13-37-14-29(30,31)15-37/h6-11H,12-15H2,1-5H3,(H,34,39)(H,32,33,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	7.5	n/a
Genetech, Inc; Gilead Connecticut, Inc. US Patent					Assay Description A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus Bt...				US Patent US8975260 (2015) BindingDB Entry DOI: 10.7270/Q2PK0DW9
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