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Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK' and Ligand = 'BDBM174408'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM174408
PNG
(US9688676, 9 (R)-2-(3-(4-amino-2-oxo-3-(4-phenoxyp...)
Show SMILES CC(C)(C=C(C#N)C(=O)N1CCC[C@H](C1)n1c2ccnc(N)c2n(-c2ccc(Oc3ccccc3)c(F)c2)c1=O)N1CCN(CCO)CC1 |r,w:3.2|
Show InChI InChI=1S/C36H41FN8O4/c1-36(2,43-17-15-41(16-18-43)19-20-46)22-25(23-38)34(47)42-14-6-7-27(24-42)44-30-12-13-40-33(39)32(30)45(35(44)48)26-10-11-31(29(37)21-26)49-28-8-4-3-5-9-28/h3-5,8-13,21-22,27,46H,6-7,14-20,24H2,1-2H3,(H2,39,40)/t27-/m1/s1
PDB
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PC cid
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US Patent
n/an/a 7.80n/an/an/an/an/a25



PRINCIPIA BIOPHARMA INC.

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of BTK kinase activity of a compound of the pre...

US Patent US9688676 (2017)


BindingDB Entry DOI: 10.7270/Q2XD0ZVX
More data for this
Ligand-Target Pair