Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK' and Ligand = 'BDBM174411'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM174411 (US9688676, 11 (R)-2-(3-(4-amino-2-oxo-3-(4-phenoxy...) Show SMILES Nc1nccc2n(C[C@@H]3CCCN3C(=O)C(=CC(CCO)CCO)C#N)c(=O)n(-c3ccc(Oc4ccccc4)cc3)c12 |r,w:16.17| Show InChI InChI=1S/C32H34N6O5/c33-20-23(19-22(13-17-39)14-18-40)31(41)36-16-4-5-25(36)21-37-28-12-15-35-30(34)29(28)38(32(37)42)24-8-10-27(11-9-24)43-26-6-2-1-3-7-26/h1-3,6-12,15,19,22,25,39-40H,4-5,13-14,16-18,21H2,(H2,34,35)/t25-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	79	n/a	n/a	n/a	n/a	n/a	25
PRINCIPIA BIOPHARMA INC. US Patent					Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of BTK kinase activity of a compound of the pre...				US Patent US9688676 (2017) BindingDB Entry DOI: 10.7270/Q2XD0ZVX
					More data for this Ligand-Target Pair