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Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK' and Ligand = 'BDBM174464'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM174464
PNG
(US9688676, 13 (S)-2-(2-((4-amino-2-oxo-3-(4-phenox...)
Show SMILES CC(C)(\C=C(/C#N)C(=O)N1CCC[C@H]1Cn1c2ccnc(N)c2n(-c2ccc(Oc3ccccc3)cc2)c1=O)N1CCN(CC1)C1COC1 |r|
Show InChI InChI=1S/C37H42N8O4/c1-37(2,42-19-17-41(18-20-42)29-24-48-25-29)21-26(22-38)35(46)43-16-6-7-28(43)23-44-32-14-15-40-34(39)33(32)45(36(44)47)27-10-12-31(13-11-27)49-30-8-4-3-5-9-30/h3-5,8-15,21,28-29H,6-7,16-20,23-25H2,1-2H3,(H2,39,40)/b26-21+/t28-/m0/s1
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US Patent
n/an/a 21n/an/an/an/an/a25



PRINCIPIA BIOPHARMA INC.

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of BTK kinase activity of a compound of the pre...

US Patent US9688676 (2017)


BindingDB Entry DOI: 10.7270/Q2XD0ZVX
More data for this
Ligand-Target Pair