Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK' and Ligand = 'BDBM200818'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM200818 (US9233111, 32) Show SMILES Cc1c(NC(=O)c2ccc(cc2)C2CC2)cc(F)cc1-c1ncnc2[nH]c(cc12)C1=CCN(CC1)C(=O)CO |t:34| Show InChI InChI=1S/C30H28FN5O3/c1-17-23(12-22(31)13-25(17)35-30(39)21-6-4-19(5-7-21)18-2-3-18)28-24-14-26(34-29(24)33-16-32-28)20-8-10-36(11-9-20)27(38)15-37/h4-8,12-14,16,18,37H,2-3,9-11,15H2,1H3,(H,35,39)(H,32,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.5	30
NOVARTIS AG US Patent					Assay Description The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...				US Patent US9233111 (2016) BindingDB Entry DOI: 10.7270/Q2ZS2V9C
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