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Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK' and Ligand = 'BDBM202134'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM202134
PNG
(US9233983, I-5)
Show SMILES OCc1c(cccc1-c1ccnc2[nH]c(cc12)-c1ccc(CN2CCN(CC2)C2CC2)cn1)N1CCOc2cc(ccc2C1=O)C1CC1
Show InChI InChI=1S/C39H40N6O3/c46-24-33-29(2-1-3-36(33)45-18-19-48-37-20-27(26-5-6-26)7-10-31(37)39(45)47)30-12-13-40-38-32(30)21-35(42-38)34-11-4-25(22-41-34)23-43-14-16-44(17-15-43)28-8-9-28/h1-4,7,10-13,20-22,26,28,46H,5-6,8-9,14-19,23-24H2,(H,40,42)
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US Patent
n/an/a 3n/an/an/an/an/an/a



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The inhibition assays were performed using the generic tyrosine kinase assay kit from C is Bio (HTRF KinEASE-TK #62TK0PEB). The assay is based on t...

US Patent US9233983 (2016)


BindingDB Entry DOI: 10.7270/Q22J69PQ
More data for this
Ligand-Target Pair