Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK' and Ligand = 'BDBM267537'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM267537 ((R)-4-(8-amino-3-(1-(4-cyanothiophene-2-carbonyl)p...) Show SMILES NC1=NC=C[N]2=C(NC(=C12)c1ccc(cc1)C(=O)Nc1cc(ccn1)C1CC1)[C@@H]1CCCN(C1)C(=O)N1CCCC1 |r,c:3,t:1,5,8| Show InChI InChI=1S/C31H35N8O2/c32-28-27-26(21-7-9-22(10-8-21)30(40)35-25-18-23(11-12-33-25)20-5-6-20)36-29(39(27)17-13-34-28)24-4-3-16-38(19-24)31(41)37-14-1-2-15-37/h7-13,17-18,20,24,36H,1-6,14-16,19H2,(H2,32,34)(H,33,35,40)/t24-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<10	n/a	n/a	7.2	25
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent					Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...				US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T
					More data for this Ligand-Target Pair