Found 2 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK' and Ligand = 'BDBM359865' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Tyrosine-protein kinase BTK
(Homo sapiens (Human)) | BDBM359865
(US9822120, Compound 19)Show SMILES Cc1ncc(COc2cc(F)cc(Oc3ccc(cc3)-c3nc(C4CC(O)(CO)C4)n4ccnc(N)c34)c2)cn1 |(8.36,-.46,;7.27,.63,;5.78,.23,;4.7,1.32,;5.09,2.8,;4.01,3.89,;2.52,3.49,;1.43,4.58,;1.83,6.07,;.74,7.16,;1.14,8.65,;-.75,6.76,;-1.15,5.27,;-2.63,4.87,;-3.03,3.39,;-1.94,2.3,;-2.34,.81,;-3.83,.41,;-4.92,1.5,;-4.52,2.99,;-4.23,-1.08,;-3.32,-2.32,;-4.23,-3.57,;-3.83,-5.06,;-4.6,-6.39,;-3.27,-7.16,;-3.67,-8.65,;-1.73,-7.16,;-.96,-8.49,;-2.5,-5.83,;-5.69,-3.09,;-7.03,-3.86,;-8.36,-3.09,;-8.36,-1.55,;-7.03,-.78,;-7.03,.76,;-5.69,-1.55,;-.06,4.18,;6.58,3.2,;7.67,2.11,)| Show InChI InChI=1S/C29H27FN6O4/c1-17-33-13-18(14-34-17)15-39-23-8-21(30)9-24(10-23)40-22-4-2-19(3-5-22)25-26-27(31)32-6-7-36(26)28(35-25)20-11-29(38,12-20)16-37/h2-10,13-14,20,37-38H,11-12,15-16H2,1H3,(H2,31,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| <100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmascience Inc.
US Patent
| Assay Description
Method A: Fluorescence polarization-based kinase assays were performed in 384 well-plate format using histidine tagged recombinant human full-length ... |
US Patent US9822120 (2017)
BindingDB Entry DOI: 10.7270/Q2639S1W |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase BTK
(Homo sapiens (Human)) | BDBM359865
(US9822120, Compound 19)Show SMILES Cc1ncc(COc2cc(F)cc(Oc3ccc(cc3)-c3nc(C4CC(O)(CO)C4)n4ccnc(N)c34)c2)cn1 |(8.36,-.46,;7.27,.63,;5.78,.23,;4.7,1.32,;5.09,2.8,;4.01,3.89,;2.52,3.49,;1.43,4.58,;1.83,6.07,;.74,7.16,;1.14,8.65,;-.75,6.76,;-1.15,5.27,;-2.63,4.87,;-3.03,3.39,;-1.94,2.3,;-2.34,.81,;-3.83,.41,;-4.92,1.5,;-4.52,2.99,;-4.23,-1.08,;-3.32,-2.32,;-4.23,-3.57,;-3.83,-5.06,;-4.6,-6.39,;-3.27,-7.16,;-3.67,-8.65,;-1.73,-7.16,;-.96,-8.49,;-2.5,-5.83,;-5.69,-3.09,;-7.03,-3.86,;-8.36,-3.09,;-8.36,-1.55,;-7.03,-.78,;-7.03,.76,;-5.69,-1.55,;-.06,4.18,;6.58,3.2,;7.67,2.11,)| Show InChI InChI=1S/C29H27FN6O4/c1-17-33-13-18(14-34-17)15-39-23-8-21(30)9-24(10-23)40-22-4-2-19(3-5-22)25-26-27(31)32-6-7-36(26)28(35-25)20-11-29(38,12-20)16-37/h2-10,13-14,20,37-38H,11-12,15-16H2,1H3,(H2,31,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | <100 | n/a | n/a | n/a | n/a |
Pharmascience Inc.
US Patent
| Assay Description
Method A: Fluorescence polarization-based kinase assays were performed in 384 well-plate format using histidine tagged recombinant human full-length ... |
US Patent US9822120 (2017)
BindingDB Entry DOI: 10.7270/Q2639S1W |
More data for this
Ligand-Target Pair | |
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