Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK [393-659]' and Ligand = 'BDBM287215'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK [393-659] (Homo sapiens (Human))	BDBM287215 (US9567339, Example A.4.11) Show SMILES Cc1c(NC2COC2)cccc1-c1ccc(C(N)=O)c2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O |t:28| Show InChI InChI=1S/C25H28N4O4S/c1-15-18(4-3-5-22(15)27-17-13-33-14-17)19-6-7-20(25(26)30)24-21(19)12-23(28-24)16-8-10-29(11-9-16)34(2,31)32/h3-8,12,17,27-28H,9-11,13-14H2,1-2H3,(H2,26,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	6.5	25
AbbVie Inc. US Patent					Assay Description The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...				US Patent US9567339 (2017) BindingDB Entry DOI: 10.7270/Q2P2715T
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