BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK [393-659]' and Ligand = 'BDBM287269'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase BTK [393-659]


(Homo sapiens (Human))		BDBM287269
PNG
(US9567339, Example A.14.1)
Show SMILES Cc1c(cccc1-n1cnc2ccc(F)cc2c1=O)-c1ccc(C(N)=O)c2[nH]c(cc12)-c1cnn(CC(C)(C)O)c1
Show InChI InChI=1S/C31H27FN6O3/c1-17-20(5-4-6-27(17)38-16-34-25-10-7-19(32)11-24(25)30(38)40)21-8-9-22(29(33)39)28-23(21)12-26(36-28)18-13-35-37(14-18)15-31(2,3)41/h4-14,16,36,41H,15H2,1-3H3,(H2,33,39)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/a6.525



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...

US Patent US9567339 (2017)


BindingDB Entry DOI: 10.7270/Q2P2715T
More data for this
Ligand-Target Pair