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Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase Fer' and Ligand = 'BDBM50501953'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase Fer


(Homo sapiens (Human))		BDBM50501953
PNG
(CHEMBL4548125)
Show SMILES CN(C)C(=O)c1cc(C#N)c(N[C@@H]2CCCC[C@@H]2N)nc1Nc1cccc(C)c1 |r|
Show InChI InChI=1S/C22H28N6O/c1-14-7-6-8-16(11-14)25-21-17(22(29)28(2)3)12-15(13-23)20(27-21)26-19-10-5-4-9-18(19)24/h6-8,11-12,18-19H,4-5,9-10,24H2,1-3H3,(H2,25,26,27)/t18-,19+/m0/s1
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n/an/a 460n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant N-terminal His-tagged human FER (SH2 domain to C-terminal) expressed in Escherichia coli assessed as decrease in FL-Peptide...

ACS Med Chem Lett 10: 737-742 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00631
BindingDB Entry DOI: 10.7270/Q2WS8XG3
More data for this
Ligand-Target Pair