Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK1' and Ligand = 'BDBM237830'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM237830 (US9394282, 6-17) Show SMILES NC(=O)c1cn(nc1Nc1ccc(F)cc1)[C@@H]1CN(Cc2cccnc2F)CC[C@H]1C#N |r| Show InChI InChI=1S/C22H21F2N7O/c23-16-3-5-17(6-4-16)28-22-18(21(26)32)12-31(29-22)19-13-30(9-7-14(19)10-25)11-15-2-1-8-27-20(15)24/h1-6,8,12,14,19H,7,9,11,13H2,(H2,26,32)(H,28,29)/t14-,19+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...				US Patent US9394282 (2016) BindingDB Entry DOI: 10.7270/Q2J10233
					More data for this Ligand-Target Pair