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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK1' and Ligand = 'BDBM366693'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM366693
PNG
(US9873709, Example 1-290 | formic acid; methyl 3- ...)
Show SMILES COC(=O)CCN1CCN(CC1)C(=O)Cn1cc(Nc2nc3c(cccn3n2)N2CCC(CO)(CC2)c2ccc(Cl)cc2)cn1
Show InChI InChI=1S/C31H38ClN9O4/c1-45-28(44)8-12-37-15-17-39(18-16-37)27(43)21-40-20-25(19-33-40)34-30-35-29-26(3-2-11-41(29)36-30)38-13-9-31(22-42,10-14-38)23-4-6-24(32)7-5-23/h2-7,11,19-20,42H,8-10,12-18,21-22H2,1H3,(H,34,36)
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US Patent
 0.180n/an/an/an/an/an/an/an/a



Duquesne University



Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...

J Med Chem 51: 68-76 (2008)


BindingDB Entry DOI: 10.7270/Q2CC130F
More data for this
Ligand-Target Pair