Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK1' and Ligand = 'BDBM489945'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM489945 (US10966980, Example 199) Show SMILES CN([C@@H]1C[C@H](CS(=O)(=O)N2CCS(=O)(=O)CC2)C1)c1ncnc2[nH]ccc12 |r,wD:2.1,4.4,(-5.92,.23,;-4.59,-.54,;-3.25,.23,;-2.85,1.71,;-1.37,1.31,;-.03,2.08,;-.03,3.62,;-.03,5.16,;-1.57,3.62,;1.51,3.62,;2.28,4.96,;3.82,4.96,;4.59,3.62,;5.92,4.39,;5.92,2.85,;3.82,2.29,;2.28,2.29,;-1.77,-.17,;-4.59,-2.08,;-5.92,-2.85,;-5.92,-4.39,;-4.59,-5.16,;-3.25,-4.39,;-1.79,-4.87,;-.88,-3.62,;-1.79,-2.38,;-3.25,-2.85,)| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.00900	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...				US Patent US10966980 (2021) BindingDB Entry DOI: 10.7270/Q29S1V59
					More data for this Ligand-Target Pair