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Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK1 [850-1154]' and Ligand = 'BDBM349070'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK1 [850-1154]


(Homo sapiens (Human))		BDBM349070
PNG
(N-(5-(4-(1-(pyridin-2- yl)ethoxy)phenyl)- [1,2,4]t...)
Show SMILES CC(Oc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12)c1ccccn1
Show InChI InChI=1S/C23H21N5O2/c1-15(19-5-2-3-14-24-19)30-18-12-10-16(11-13-18)20-6-4-7-21-25-23(27-28(20)21)26-22(29)17-8-9-17/h2-7,10-15,17H,8-9H2,1H3,(H,26,27,29)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair