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Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK1 [850-1154]' and Ligand = 'BDBM349154'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK1 [850-1154]


(Homo sapiens (Human))		BDBM349154
PNG
(Cyclopropanecarboxylic acid {5-[4-(3-cyano-azetidi...)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(cc3)N3CC(C3)C#N)n2n1)C1CC1
Show InChI InChI=1S/C20H18N6O/c21-10-13-11-25(12-13)16-8-6-14(7-9-16)17-2-1-3-18-22-20(24-26(17)18)23-19(27)15-4-5-15/h1-3,6-9,13,15H,4-5,11-12H2,(H,23,24,27)
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair